node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Veis_0002 | Veis_3725 | Veis_0002 | Veis_3725 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: ilo:IL0002 DNA polymerase sliding clamp subunit. | 0.912 |
Veis_0002 | rnhB | Veis_0002 | Veis_1452 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.798 |
Veis_0002 | thyA | Veis_0002 | Veis_3172 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.712 |
Veis_1453 | Veis_4383 | Veis_1453 | Veis_4383 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | KEGG: ana:alr2678 probable acyl-CoA synthase. | 0.665 |
Veis_1453 | fabZ | Veis_1453 | Veis_1449 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.780 |
Veis_1453 | lpxA | Veis_1453 | Veis_1450 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.857 |
Veis_1453 | lpxB | Veis_1453 | Veis_1451 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.873 |
Veis_1453 | lpxD | Veis_1453 | Veis_1448 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.736 |
Veis_1453 | rnhB | Veis_1453 | Veis_1452 | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.880 |
Veis_3725 | Veis_0002 | Veis_3725 | Veis_0002 | KEGG: ilo:IL0002 DNA polymerase sliding clamp subunit. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.912 |
Veis_3725 | rnhB | Veis_3725 | Veis_1452 | KEGG: ilo:IL0002 DNA polymerase sliding clamp subunit. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.798 |
Veis_3725 | thyA | Veis_3725 | Veis_3172 | KEGG: ilo:IL0002 DNA polymerase sliding clamp subunit. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.712 |
Veis_4383 | Veis_1453 | Veis_4383 | Veis_1453 | KEGG: ana:alr2678 probable acyl-CoA synthase. | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 0.665 |
Veis_4383 | fabZ | Veis_4383 | Veis_1449 | KEGG: ana:alr2678 probable acyl-CoA synthase. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.835 |
Veis_4383 | lpxD | Veis_4383 | Veis_1448 | KEGG: ana:alr2678 probable acyl-CoA synthase. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.783 |
Veis_4383 | rnhB | Veis_4383 | Veis_1452 | KEGG: ana:alr2678 probable acyl-CoA synthase. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.852 |
fabZ | Veis_1453 | Veis_1449 | Veis_1453 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: pol:Bpro_2680 tRNA/rRNA methyltransferase (SpoU). | 0.780 |
fabZ | Veis_4383 | Veis_1449 | Veis_4383 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | KEGG: ana:alr2678 probable acyl-CoA synthase. | 0.835 |
fabZ | lpxA | Veis_1449 | Veis_1450 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.993 |
fabZ | lpxB | Veis_1449 | Veis_1451 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.902 |