node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_1448 | Aave_3145 | Aave_1448 | Aave_3145 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | 0.916 |
Aave_1448 | glyA | Aave_1448 | Aave_2992 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
Aave_1448 | thyA | Aave_1448 | Aave_1450 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Aave_3145 | Aave_1448 | Aave_3145 | Aave_1448 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.916 |
Aave_3145 | Aave_4058 | Aave_3145 | Aave_4058 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rfr:Rfer_0654 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.940 |
Aave_3145 | folD | Aave_3145 | Aave_2459 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.963 |
Aave_3145 | glyA | Aave_3145 | Aave_2992 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
Aave_3145 | thyA | Aave_3145 | Aave_1450 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.935 |
Aave_3975 | Aave_4022 | Aave_3975 | Aave_4022 | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
Aave_3975 | dut | Aave_3975 | Aave_1329 | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Aave_3975 | surE | Aave_3975 | Aave_1414 | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
Aave_3975 | thyA | Aave_3975 | Aave_1450 | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
Aave_3975 | tmk | Aave_3975 | Aave_3412 | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
Aave_4022 | Aave_3975 | Aave_4022 | Aave_3975 | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | PFAM: 5-nucleotidase; KEGG: pol:Bpro_0738 5-nucleotidase. | 0.900 |
Aave_4022 | dut | Aave_4022 | Aave_1329 | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
Aave_4022 | surE | Aave_4022 | Aave_1414 | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
Aave_4022 | thyA | Aave_4022 | Aave_1450 | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.906 |
Aave_4022 | tmk | Aave_4022 | Aave_3412 | 5'-nucleotidase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: mxa:MXAN_2236 putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.915 |
Aave_4058 | Aave_3145 | Aave_4058 | Aave_3145 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rfr:Rfer_0654 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: pol:Bpro_1868 glycine cleavage system T protein. | 0.940 |
Aave_4058 | folD | Aave_4058 | Aave_2459 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rfr:Rfer_0654 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |