node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_0002 | Spea_2238 | Spea_0002 | Spea_2238 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase, RecQ family; KEGG: pin:Ping_3396 23S rRNA (Gm2251)-methyltransferase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases. | 0.744 |
Spea_0002 | Spea_2292 | Spea_0002 | Spea_2292 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: UvrD/REP helicase; DNA topoisomerase type IA zn finger domain protein; KEGG: sfr:Sfri_0452 UvrD/REP helicase. | 0.857 |
Spea_0002 | polA | Spea_0002 | Spea_0102 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
Spea_0002 | recA | Spea_0002 | Spea_1195 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.920 |
Spea_0002 | xni | Spea_0002 | Spea_2976 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 5'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.927 |
Spea_1169 | Spea_1595 | Spea_1169 | Spea_1595 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | 0.590 |
Spea_1169 | Spea_2196 | Spea_1169 | Spea_2196 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | PFAM: peptidase S24 and S26 domain protein; KEGG: sfr:Sfri_1963 putative prophage repressor; Belongs to the peptidase S24 family. | 0.718 |
Spea_1169 | Spea_2292 | Spea_1169 | Spea_2292 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | PFAM: UvrD/REP helicase; DNA topoisomerase type IA zn finger domain protein; KEGG: sfr:Sfri_0452 UvrD/REP helicase. | 0.503 |
Spea_1169 | Spea_3032 | Spea_1169 | Spea_3032 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | TIGRFAM: DNA repair protein RadA; KEGG: slo:Shew_2807 DNA repair protein RadA. | 0.576 |
Spea_1169 | lexA | Spea_1169 | Spea_3997 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.718 |
Spea_1169 | polA | Spea_1169 | Spea_0102 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.562 |
Spea_1169 | recA | Spea_1169 | Spea_1195 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.897 |
Spea_1595 | Spea_1169 | Spea_1595 | Spea_1169 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.590 |
Spea_1595 | Spea_2292 | Spea_1595 | Spea_2292 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | PFAM: UvrD/REP helicase; DNA topoisomerase type IA zn finger domain protein; KEGG: sfr:Sfri_0452 UvrD/REP helicase. | 0.427 |
Spea_1595 | Spea_3032 | Spea_1595 | Spea_3032 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | TIGRFAM: DNA repair protein RadA; KEGG: slo:Shew_2807 DNA repair protein RadA. | 0.909 |
Spea_1595 | polA | Spea_1595 | Spea_0102 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.498 |
Spea_1595 | recA | Spea_1595 | Spea_1195 | Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.939 |
Spea_2196 | Spea_1169 | Spea_2196 | Spea_1169 | PFAM: peptidase S24 and S26 domain protein; KEGG: sfr:Sfri_1963 putative prophage repressor; Belongs to the peptidase S24 family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.718 |
Spea_2196 | polA | Spea_2196 | Spea_0102 | PFAM: peptidase S24 and S26 domain protein; KEGG: sfr:Sfri_1963 putative prophage repressor; Belongs to the peptidase S24 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.409 |
Spea_2196 | recA | Spea_2196 | Spea_1195 | PFAM: peptidase S24 and S26 domain protein; KEGG: sfr:Sfri_1963 putative prophage repressor; Belongs to the peptidase S24 family. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.973 |