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lpxK lpxK kdtA kdtA lpxB lpxB lpxA lpxA lpxC lpxC Dshi_0079 Dshi_0079 yrbH yrbH lpxD lpxD kdsA kdsA kdsB kdsB Dshi_1503 Dshi_1503
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (337 aa)    
Predicted Functional Partners:
kdtA
three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 0.999
lpxB
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
 0.996
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.900
lpxC
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
  
 0.900
Dshi_0079
PFAM: lipid A biosynthesis acyltransferase KEGG: sil:SPO1058 acyltransferase, HtrB family.
 
  
 0.884
yrbH
KEGG: rde:RD1_0368 arabinose 5-phosphate isomerase TIGRFAM: KpsF/GutQ family protein PFAM: CBS domain containing protein; sugar isomerase (SIS); Belongs to the SIS family. GutQ/KpsF subfamily.
 
   
 0.875
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
  
 0.871
kdsA
TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase PFAM: DAHP synthetase I/KDSA; NCBI conserved domains: kdsA; high swissprot hit to 2-dehydro-3-deoxyphosphooctonate aldolase from Bradyrhizobium japonicum; high Ref ZP hit to 2-dehydro-3-deoxyphosphooctonate aldolase [Roseobacter sp. CCS2].
 
  
 0.864
kdsB
KEGG: sil:SPO0038 3-deoxy-manno-octulosonate cytidylyltransferase TIGRFAM: 3-deoxy-D-manno-octulosonate cytidylyltransferase PFAM: acylneuraminate cytidylyltransferase.
 
  
 0.830
Dshi_1503
COG: COG3494 - Uncharacterized protein conserved in bacteria, PFAM: pfam06230 Protein of unknown function (DUF1009).
 
   
 0.828
Your Current Organism:
Dinoroseobacter shibae
NCBI taxonomy Id: 398580
Other names: D. shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DFL 12, Dinoroseobacter shibae DFL 12 = DSM 16493, Dinoroseobacter shibae DSM 16493, Dinoroseobacter shibae DSM 16493 = DFL 12, Jannaschia sp. DFL-12
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