node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0570 | Spro_3548 | Spro_0570 | Spro_3548 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | KEGG: yen:YE1115 putative heat shock protein. | 0.969 |
Spro_0570 | dnaJ | Spro_0570 | Spro_0693 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.974 |
Spro_0570 | dnaK | Spro_0570 | Spro_0692 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.969 |
Spro_0570 | groL | Spro_0570 | Spro_0409 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.916 |
Spro_0570 | groS | Spro_0570 | Spro_0408 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.806 |
Spro_0570 | grpE | Spro_0570 | Spro_3684 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.789 |
Spro_0570 | hscA | Spro_0570 | Spro_3623 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.969 |
Spro_0570 | hslU | Spro_0570 | Spro_4793 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.731 |
Spro_2430 | groL | Spro_2430 | Spro_0409 | PFAM: NADH-ubiquinone oxidoreductase chain 49kDa; NADH dehydrogenase (ubiquinone) 30 kDa subunit; KEGG: stm:STM2849 hydrogenase 3 large subunit. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.896 |
Spro_3548 | Spro_0570 | Spro_3548 | Spro_0570 | KEGG: yen:YE1115 putative heat shock protein. | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | 0.969 |
Spro_3548 | dnaJ | Spro_3548 | Spro_0693 | KEGG: yen:YE1115 putative heat shock protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.919 |
Spro_3548 | groL | Spro_3548 | Spro_0409 | KEGG: yen:YE1115 putative heat shock protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.828 |
Spro_3548 | groS | Spro_3548 | Spro_0408 | KEGG: yen:YE1115 putative heat shock protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.795 |
Spro_3548 | grpE | Spro_3548 | Spro_3684 | KEGG: yen:YE1115 putative heat shock protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.912 |
Spro_3548 | hslU | Spro_3548 | Spro_4793 | KEGG: yen:YE1115 putative heat shock protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.543 |
Spro_3548 | htpG | Spro_3548 | Spro_1138 | KEGG: yen:YE1115 putative heat shock protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.894 |
dnaJ | Spro_0570 | Spro_0693 | Spro_0570 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. | 0.974 |
dnaJ | Spro_3548 | Spro_0693 | Spro_3548 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | KEGG: yen:YE1115 putative heat shock protein. | 0.919 |
dnaJ | dnaK | Spro_0693 | Spro_0692 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
dnaJ | groL | Spro_0693 | Spro_0409 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.880 |