node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spro_0708 | Spro_0733 | Spro_0708 | Spro_0733 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | 0.517 |
Spro_0708 | Spro_0734 | Spro_0708 | Spro_0734 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eca:ECA3848 acetolactate synthase isozyme I large subunit. | 0.871 |
Spro_0708 | Spro_0748 | Spro_0708 | Spro_0748 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | KEGG: yen:YE0658 acetolactate synthase isozyme III large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. | 0.872 |
Spro_0708 | Spro_0749 | Spro_0708 | Spro_0749 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: yen:YE0659 acetolactate synthase isozyme III small subunit. | 0.872 |
Spro_0708 | Spro_3294 | Spro_0708 | Spro_3294 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_3951 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. | 0.858 |
Spro_0708 | Spro_3956 | Spro_0708 | Spro_3956 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: kpn:KPN_03360 putative pyruvate decarboxylase; Belongs to the TPP enzyme family. | 0.808 |
Spro_0708 | Spro_4760 | Spro_0708 | Spro_4760 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yen:YE0148 acetolactate synthase isozyme II large subunit. | 0.875 |
Spro_0708 | ilvC | Spro_0708 | Spro_4751 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.984 |
Spro_0708 | ilvD | Spro_0708 | Spro_4757 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | KEGG: eca:ECA4226 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.912 |
Spro_0708 | leuB | Spro_0708 | Spro_0744 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.931 |
Spro_0733 | Spro_0708 | Spro_0733 | Spro_0708 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.517 |
Spro_0733 | Spro_0734 | Spro_0733 | Spro_0734 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eca:ECA3848 acetolactate synthase isozyme I large subunit. | 0.995 |
Spro_0733 | Spro_0748 | Spro_0733 | Spro_0748 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | KEGG: yen:YE0658 acetolactate synthase isozyme III large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. | 0.972 |
Spro_0733 | Spro_0749 | Spro_0733 | Spro_0749 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: yen:YE0659 acetolactate synthase isozyme III small subunit. | 0.907 |
Spro_0733 | Spro_3294 | Spro_0733 | Spro_3294 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_3951 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. | 0.972 |
Spro_0733 | Spro_3956 | Spro_0733 | Spro_3956 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: kpn:KPN_03360 putative pyruvate decarboxylase; Belongs to the TPP enzyme family. | 0.973 |
Spro_0733 | Spro_4760 | Spro_0733 | Spro_4760 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yen:YE0148 acetolactate synthase isozyme II large subunit. | 0.971 |
Spro_0733 | ilvC | Spro_0733 | Spro_4751 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.977 |
Spro_0733 | ilvD | Spro_0733 | Spro_4757 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | KEGG: eca:ECA4226 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.517 |
Spro_0733 | leuB | Spro_0733 | Spro_0744 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.974 |