node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR70423.1 | ABR72577.1 | Mmwyl1_1494 | Mmwyl1_3676 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | 0.816 |
ABR70423.1 | hisB | Mmwyl1_1494 | Mmwyl1_0753 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pau:PA14_67930 imidazoleglycerol-phosphate dehydratase. | 0.935 |
ABR70423.1 | hisC | Mmwyl1_1494 | Mmwyl1_1133 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: azo:azo3348 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.917 |
ABR70423.1 | hisD | Mmwyl1_1494 | Mmwyl1_2406 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.935 |
ABR70423.1 | hisE | Mmwyl1_1494 | Mmwyl1_0744 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pfl:PFL_0423 phosphoribosyl-ATP pyrophosphohydrolase. | 0.935 |
ABR70423.1 | hisF | Mmwyl1_1494 | Mmwyl1_0751 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.993 |
ABR70423.1 | hisG | Mmwyl1_1494 | Mmwyl1_2407 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.935 |
ABR70423.1 | hisH | Mmwyl1_1494 | Mmwyl1_0752 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.994 |
ABR70423.1 | hisI | Mmwyl1_1494 | Mmwyl1_2431 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
ABR70423.1 | hisZ | Mmwyl1_1494 | Mmwyl1_2627 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.917 |
ABR72577.1 | ABR70423.1 | Mmwyl1_3676 | Mmwyl1_1494 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | 0.816 |
ABR72577.1 | hisB | Mmwyl1_3676 | Mmwyl1_0753 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pau:PA14_67930 imidazoleglycerol-phosphate dehydratase. | 0.816 |
ABR72577.1 | hisD | Mmwyl1_3676 | Mmwyl1_2406 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.816 |
ABR72577.1 | hisE | Mmwyl1_3676 | Mmwyl1_0744 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pfl:PFL_0423 phosphoribosyl-ATP pyrophosphohydrolase. | 0.807 |
ABR72577.1 | hisF | Mmwyl1_3676 | Mmwyl1_0751 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.816 |
ABR72577.1 | hisG | Mmwyl1_3676 | Mmwyl1_2407 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.816 |
ABR72577.1 | hisH | Mmwyl1_3676 | Mmwyl1_0752 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.816 |
ABR72577.1 | hisI | Mmwyl1_3676 | Mmwyl1_2431 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.816 |
ABR72577.1 | hisZ | Mmwyl1_3676 | Mmwyl1_2627 | PFAM: aminotransferase class I and II; KEGG: cps:CPS_1142 CobC protein. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.788 |
hisB | ABR70423.1 | Mmwyl1_0753 | Mmwyl1_1494 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pau:PA14_67930 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: afm:Afu5g06160 5-proFAR isomerase; Belongs to the HisA/HisF family. | 0.935 |