node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GFO_0332 | GFO_0333 | GFO_0332 | GFO_0333 | Methionine synthase N-terminal domain-like protein. | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
GFO_0332 | GFO_2955 | GFO_0332 | GFO_2955 | Methionine synthase N-terminal domain-like protein. | Conserved hypothetical protein. | 0.900 |
GFO_0332 | ahcY | GFO_0332 | GFO_3067 | Methionine synthase N-terminal domain-like protein. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.928 |
GFO_0332 | mdeA | GFO_0332 | GFO_2175 | Methionine synthase N-terminal domain-like protein. | Methionine gamma-lyase. | 0.934 |
GFO_0332 | metK | GFO_0332 | GFO_0314 | Methionine synthase N-terminal domain-like protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.928 |
GFO_0333 | GFO_0332 | GFO_0333 | GFO_0332 | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase N-terminal domain-like protein. | 0.999 |
GFO_0333 | GFO_2955 | GFO_0333 | GFO_2955 | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Conserved hypothetical protein. | 0.900 |
GFO_0333 | ahcY | GFO_0333 | GFO_3067 | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.926 |
GFO_0333 | mdeA | GFO_0333 | GFO_2175 | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine gamma-lyase. | 0.920 |
GFO_0333 | metK | GFO_0333 | GFO_0314 | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.926 |
GFO_2955 | GFO_0332 | GFO_2955 | GFO_0332 | Conserved hypothetical protein. | Methionine synthase N-terminal domain-like protein. | 0.900 |
GFO_2955 | GFO_0333 | GFO_2955 | GFO_0333 | Conserved hypothetical protein. | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
GFO_2955 | mdeA | GFO_2955 | GFO_2175 | Conserved hypothetical protein. | Methionine gamma-lyase. | 0.900 |
GFO_2955 | metK | GFO_2955 | GFO_0314 | Conserved hypothetical protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
ahcY | GFO_0332 | GFO_3067 | GFO_0332 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methionine synthase N-terminal domain-like protein. | 0.928 |
ahcY | GFO_0333 | GFO_3067 | GFO_0333 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydrofolate:homocysteine methyltransferase-cobalamin binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.926 |
ahcY | metK | GFO_3067 | GFO_0314 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.761 |
cbbE | gmk | GFO_0377 | GFO_3432 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.466 |
cbbE | guaA | GFO_0377 | GFO_2228 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.557 |
cbbE | metK | GFO_0377 | GFO_0314 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.745 |