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cysG cysG hemC hemC sat sat Rmag_0853 Rmag_0853 hemE hemE Rmag_0678 Rmag_0678 Rmag_0858 Rmag_0858 Rmag_0409 Rmag_0409 hemA hemA Rmag_0125 Rmag_0125 Rmag_0688 Rmag_0688
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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cysGuroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (472 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.985
sat
KEGG: tbd:Tbd_0874 ATP-sulfurylase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family.
  
  
 0.966
Rmag_0853
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.965
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.953
Rmag_0678
PFAM: Rieske [2Fe-2S] domain protein; KEGG: tbd:Tbd_0271 putative dioxygenase ferredoxin subunit.
  
  
 0.877
Rmag_0858
TIGRFAM: cobyrinic acid a,c-diamide synthase; PFAM: HesB/YadR/YfhF-family protein; Cobyrinic acid a,c-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: tbd:Tbd_2473 cobyrinic acid a,c-diamide synthase CbiA.
 
   
 0.787
Rmag_0409
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: tcx:Tcr_0154 porphobilinogen synthase; Belongs to the ALAD family.
 
  
 0.768
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.697
Rmag_0125
PFAM: phosphate transporter; KEGG: csa:Csal_0712 phosphate transporter.
  
  
 0.686
Rmag_0688
TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: mca:MCA0592 nitrite reductase [NAD(P)H], large subunit.
  
 0.676
Your Current Organism:
Ruthia magnifica
NCBI taxonomy Id: 413404
Other names: C. Ruthia magnifica str. Cm (Calyptogena magnifica), Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica), Candidatus Ruthia magnifica strain Cm (Calyptogena magnifica), Ruthia magnifica str. Cm (Calyptogena magnifica)
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