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kae1 kae1 Hbut_0433 Hbut_0433 hjc hjc Hbut_0432 Hbut_0432 rps24e rps24e rps27ae rps27ae rps15 rps15 Hbut_0898 Hbut_0898 Hbut_0770 Hbut_0770 Hbut_0484 Hbut_0484 spt4 spt4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
kae1Metal-dependent protease, possible chaperone activity, QR17; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family. (363 aa)    
Predicted Functional Partners:
Hbut_0433
Predicted serine/threonine kinase.
   
 0.993
hjc
Holliday junction resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
     
 0.963
Hbut_0432
Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
     
 0.905
rps24e
30S ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family.
  
    0.900
rps27ae
30S ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family.
       0.891
rps15
30S ribosomal protein S13e.
 
   
 0.819
Hbut_0898
Universally conserved protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
      
 0.785
Hbut_0770
Universally conserved protein; The protein has a dsRNA binding domain.
 
 
 0.775
Hbut_0484
Hypothetical protein.
    
 
 0.734
spt4
DNA-directed RNA polymerase subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
 
     0.716
Your Current Organism:
Hyperthermus butylicus
NCBI taxonomy Id: 415426
Other names: H. butylicus DSM 5456, Hyperthermus butylicus DSM 5456, Hyperthermus butylicus str. DSM 5456, Hyperthermus butylicus strain DSM 5456
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