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nadE nadE nadK nadK Hbut_1211 Hbut_1211 Hbut_1560 Hbut_1560 cobB cobB Hbut_1124 Hbut_1124 nnr nnr Hbut_0063 Hbut_0063 Hbut_0679 Hbut_0679 Hbut_1195 Hbut_1195 Hbut_0680 Hbut_0680
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (276 aa)    
Predicted Functional Partners:
nadK
ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.969
Hbut_1211
Nicotinamide-nucleotide adenylyltransferase.
 
  
 0.942
Hbut_1560
Nicotinamide-nucleotide adenylyltransferase.
 
  
 0.942
cobB
NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.
    
 0.925
Hbut_1124
Predicted Nicotinic acid phosphoribosyltransferase.
 
  
 0.827
nnr
Conserved archaeal protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family.
 
   
 0.633
Hbut_0063
iIsochorismatase family protein.
  
  
 0.628
Hbut_0679
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
     
 0.609
Hbut_1195
Glutamine synthetase.
  
  
 0.562
Hbut_0680
Quinolinate synthetase A.
  
  
 0.559
Your Current Organism:
Hyperthermus butylicus
NCBI taxonomy Id: 415426
Other names: H. butylicus DSM 5456, Hyperthermus butylicus DSM 5456, Hyperthermus butylicus str. DSM 5456, Hyperthermus butylicus strain DSM 5456
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