node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tlet_0653 | fhs | Tlet_0653 | Tlet_1513 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.976 |
Tlet_0653 | folD | Tlet_0653 | Tlet_1514 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.967 |
Tlet_0653 | gcvPB | Tlet_0653 | Tlet_1956 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.528 |
Tlet_0653 | gcvT | Tlet_0653 | Tlet_1959 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
Tlet_0653 | glyA | Tlet_0653 | Tlet_0763 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
Tlet_0653 | purH | Tlet_0653 | Tlet_1909 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bca:BCE_0327 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.909 |
Tlet_0653 | purN | Tlet_0653 | Tlet_1910 | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.997 |
Tlet_1944 | glyA | Tlet_1944 | Tlet_0763 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; KEGG: mta:Moth_1946 L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
fhs | Tlet_0653 | Tlet_1513 | Tlet_0653 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.976 |
fhs | folD | Tlet_1513 | Tlet_1514 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvH | Tlet_1513 | Tlet_1958 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.433 |
fhs | gcvPB | Tlet_1513 | Tlet_1956 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.494 |
fhs | gcvT | Tlet_1513 | Tlet_1959 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
fhs | glyA | Tlet_1513 | Tlet_0763 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
fhs | purH | Tlet_1513 | Tlet_1909 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bca:BCE_0327 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.976 |
fhs | purN | Tlet_1513 | Tlet_1910 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.968 |
folD | Tlet_0653 | Tlet_1514 | Tlet_0653 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | IMP cyclohydrolase; PFAM: MGS domain protein; KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.967 |
folD | fhs | Tlet_1514 | Tlet_1513 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.998 |
folD | gcvH | Tlet_1514 | Tlet_1958 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.513 |
folD | gcvPB | Tlet_1514 | Tlet_1956 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.674 |