STRINGSTRING
dnaK dnaK Aasi_0943 Aasi_0943 dnaJ dnaJ grpE grpE groL groL groS groS Aasi_0963 Aasi_0963 Aasi_0820 Aasi_0820 Aasi_1304 Aasi_1304 Aasi_0999 Aasi_0999 Aasi_1160 Aasi_1160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaKHypothetical protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (632 aa)    
Predicted Functional Partners:
Aasi_0943
Hypothetical protein; PFAM: PF01609, Transposase, IS4-like.
   
 0.999
dnaJ
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, Dna [...]
 0.999
grpE
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...]
 
 0.998
groL
Hypothetical protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.993
groS
Hypothetical protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.987
Aasi_0963
Hypothetical protein; PROSITE: PS00211, ABC transporter-like; PROFILE: PS50929, ABC transporter, transmembrane region, type 1;PS50893, ABC transporter-like; SUPERFAMILY: SSF90123, ABC transporter, transmembrane region, type 1; PFAM: PF00664, ABC transporter, transmembrane region;PF00005, ABC transporter-like; PRODOM: PD000006, ABC transporter-like; SMART: SM00382, AAA+ ATPase, core.
  
 0.923
Aasi_0820
Hypothetical protein; PFAM: PF04389, Peptidase M28.
  
 0.918
Aasi_1304
Hypothetical protein; PFAM: PF08238, Sel1-like;PF04564, U box; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical;G3DSA:3.30.40.10, Zinc finger, RING/FYVE/PHD-type; SMART: SM00671, Sel1-like;SM00504, U box.
  
 0.918
Aasi_0999
Hypothetical protein; PFAM: PF01609, Transposase, IS4-like.
   
 0.905
Aasi_1160
Hypothetical protein; PROSITE: PS01150, NADH dehydrogenase (ubiquinone), 20 kDa subunit; PANTHER: PTHR11995:SF2, NADH dehydrogenase (ubiquinone), 20 kDa subunit;PTHR11995, [NiFe]-hydrogenase-3-type complex, small subunit/NADH:quinone oxidoreductase, subunit NuoB; PFAM: PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit; TIGRFAMS: TIGR01957, NADH dehydrogenase (ubiquinone), 20 kDa subunit.
   
 0.905
Your Current Organism:
Amoebophilus asiaticus
NCBI taxonomy Id: 452471
Other names: C. Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus str. 5a2, Candidatus Amoebophilus asiaticus strain 5a2
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