STRINGSTRING
guaAA guaAA Igni_0637 Igni_0637 Igni_0179 Igni_0179 Igni_0542 Igni_0542 purA purA Igni_0295 Igni_0295 Igni_0400 Igni_0400 rpl2 rpl2 rpl11 rpl11 Igni_0165 Igni_0165 Igni_0892 Igni_0892
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
guaAAGlutamine amidotransferase class-I; Catalyzes the synthesis of GMP from XMP. (188 aa)    
Predicted Functional Partners:
Igni_0637
PFAM: GMP synthase domain protein; PP-loop domain protein.
  
 0.998
Igni_0179
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.926
Igni_0542
PFAM: NADH-ubiquinone oxidoreductase, chain 49kDa; NADH dehydrogenase (ubiquinone), 30 kDa subunit.
  
  
 0.907
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
 0.874
Igni_0295
Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
  
    0.843
Igni_0400
TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
  
 0.827
rpl2
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
  
 0.770
rpl11
LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
   
    0.765
Igni_0165
TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase.
 
  
 0.752
Igni_0892
TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein.
  
    0.723
Your Current Organism:
Ignicoccus hospitalis
NCBI taxonomy Id: 453591
Other names: I. hospitalis KIN4/I, Ignicoccus hospitalis DSM 18386, Ignicoccus hospitalis JCM 14125, Ignicoccus hospitalis KIN4/I, Ignicoccus hospitalis str. KIN4/I, Ignicoccus hospitalis strain KIN4/I
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