STRINGSTRING
rfcL rfcL pcn pcn Mboo_1673 Mboo_1673 fen fen Mboo_2098 Mboo_2098 priS priS Mboo_0179 Mboo_0179 Mboo_1108 Mboo_1108 priL priL lig lig Mboo_1253 Mboo_1253
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rfcLAAA ATPase, central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (481 aa)    
Predicted Functional Partners:
pcn
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 0.957
Mboo_1673
PFAM: MCM family protein; KEGG: mhu:Mhun_0985 MCM; Belongs to the MCM family.
 
 
 0.922
fen
XPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...]
  
 0.881
Mboo_2098
PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mhu:Mhun_2941 nucleic acid binding, OB-fold, tRNA/helicase-type.
 
 0.845
priS
Putative DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer s [...]
  
 0.844
Mboo_0179
PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: mhu:Mhun_2542 nucleic acid binding, OB-fold, tRNA/helicase-type.
 
 0.843
Mboo_1108
PFAM: DNA polymerase B, exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mhu:Mhun_1156 DNA polymerase B region.
  
 0.830
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 0.818
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.778
Mboo_1253
PFAM: DNA polymerase B region; KEGG: afu:AF0693m DNA polymerase II.
   
 0.763
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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