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ilvD ilvD ilvC ilvC ilvE ilvE Mboo_1443 Mboo_1443 Mboo_1815 Mboo_1815 Mboo_1444 Mboo_1444 Mboo_0599 Mboo_0599 leuC leuC Mboo_2077 Mboo_2077 Mboo_0602 Mboo_0602 leuD leuD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ilvDKEGG: mhu:Mhun_0139 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (550 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.997
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.995
Mboo_1443
KEGG: mhu:Mhun_1242 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein.
  
 0.989
Mboo_1815
PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mhu:Mhun_2360 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.973
Mboo_1444
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1241 acetolactate synthase, small subunit.
 
 
 0.895
Mboo_0599
KEGG: mhu:Mhun_1800 3-isopropylmalate dehydratase; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein.
  
  
 0.851
leuC
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.851
Mboo_2077
PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mhu:Mhun_2363 3-isopropylmalate dehydrogenase.
 
  
 0.834
Mboo_0602
PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mhu:Mhun_1797 3-isopropylmalate dehydrogenase.
 
  
 0.829
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.807
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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