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hemC hemC hemD hemD hemB hemB nirE nirE hemE hemE hemA hemA cysG cysG hemL hemL hemY hemY hemX hemX hemF hemF
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query proteins and first shell of interactors
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second shell of interactors
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hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
hemD
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.998
hemB
Delta-aminolevulinic acid dehydratase; silverDB:etchr01439; Belongs to the ALAD family.
 
 0.995
nirE
Phage-related protein; silverDB:etchr01705.
  
 0.991
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.985
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.984
cysG
uroporphyrin-III C-methylase, siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.983
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; silverDB:etchr00870.
 
  
 0.924
hemY
Protein HemY; silverDB:etchr00208.
  
  
 0.812
hemX
Uroporphyrinogen III methylase; silverDB:etchr00209.
  
  
 0.795
hemF
Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
  
 0.596
Your Current Organism:
Erwinia tasmaniensis
NCBI taxonomy Id: 465817
Other names: E. tasmaniensis Et1/99, Erwinia tasmaniensis Et1/99, Erwinia tasmaniensis str. Et1/99, Erwinia tasmaniensis strain Et1/99
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