STRINGSTRING
panC panC panD panD panB panB panE panE coaA coaA goaG goaG cmk cmk dfp dfp bacA bacA folK folK pcnB pcnB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
panCPantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
  
  0.995
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     0.991
panE
2-dehydropantoate 2-reductase (KPA reductase); Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
  
  
  0.911
coaA
Pantothenate kinase; silverDB:etchr00146.
     
  0.900
goaG
4-aminobutyrate aminotransferase; silverDB:etchr01181; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
    
  0.900
cmk
Cytidylate kinase; silverDB:etchr02131.
 
      0.900
dfp
Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
  
  
  0.846
bacA
Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904.
  
  
 0.701
folK
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; silverDB:etchr00849.
 
     0.638
pcnB
Poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
       0.561
Your Current Organism:
Erwinia tasmaniensis
NCBI taxonomy Id: 465817
Other names: E. tasmaniensis Et1/99, Erwinia tasmaniensis Et1/99, Erwinia tasmaniensis str. Et1/99, Erwinia tasmaniensis strain Et1/99
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