node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGO_0416 | SGO_1371 | SGO_0416 | SGO_1371 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | 0.515 |
SGO_0416 | aroB | SGO_0416 | SGO_1373 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.944 |
SGO_0416 | pabB | SGO_0416 | SGO_0307 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Chorismate binding enzyme; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553. | 0.410 |
SGO_0416 | pheA | SGO_0416 | SGO_1366 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842. | 0.500 |
SGO_1371 | SGO_0416 | SGO_1371 | SGO_0416 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.515 |
SGO_1371 | aroA | SGO_1371 | SGO_1368 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.989 |
SGO_1371 | aroB | SGO_1371 | SGO_1373 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.862 |
SGO_1371 | aroC | SGO_1371 | SGO_1372 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.956 |
SGO_1371 | aroD | SGO_1371 | SGO_1375 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.521 |
SGO_1371 | aroE | SGO_1371 | SGO_1374 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.694 |
SGO_1371 | aroK | SGO_1371 | SGO_1367 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.712 |
SGO_1371 | pabB | SGO_1371 | SGO_0307 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Chorismate binding enzyme; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553. | 0.510 |
SGO_1371 | pheA | SGO_1371 | SGO_1366 | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842. | 0.980 |
aroA | SGO_1371 | SGO_1368 | SGO_1371 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Prephenate dehydrogenase; Identified by match to protein family HMM PF02153; match to protein family HMM PF03446; match to protein family HMM PF03807. | 0.989 |
aroA | aroB | SGO_1368 | SGO_1373 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.983 |
aroA | aroC | SGO_1368 | SGO_1372 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.996 |
aroA | aroD | SGO_1368 | SGO_1375 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. | 0.407 |
aroA | aroE | SGO_1368 | SGO_1374 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.966 |
aroA | aroK | SGO_1368 | SGO_1367 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.996 |
aroA | pabB | SGO_1368 | SGO_0307 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate binding enzyme; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553. | 0.635 |