STRINGSTRING
dnaA dnaA ACS22944.1 ACS22944.1 recF recF ACS26048.1 ACS26048.1 ACS25983.1 ACS25983.1 ACS24095.1 ACS24095.1 ACS24082.1 ACS24082.1 rnpA rnpA ACS26061.1 ACS26061.1 recR recR ACS22945.1 ACS22945.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (450 aa)    
Predicted Functional Partners:
ACS22944.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 0.991
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
 
  
 0.893
ACS26048.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
 
 
 0.865
ACS25983.1
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: gtn:GTNG_3340 3-hydroxybutyryl-CoA dehydrogenase.
 
 
    0.810
ACS24095.1
KEGG: gtn:GTNG_1188 hypothetical protein.
    
 
 0.801
ACS24082.1
PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: afl:Aflv_1513 3-hydroxyacyl-CoA dehydrogenase.
 
 
    0.762
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.670
ACS26061.1
PFAM: Cobyrinic acid ac-diamide synthase; KEGG: gtn:GTNG_3436 centromere-like function involved in forespore chromosome partition.
 
 
 0.639
recR
Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
  
 0.617
ACS22945.1
TIGRFAM: S4 domain protein YaaA; KEGG: gka:GK0003 hypothetical protein.
  
  
 0.608
Your Current Organism:
Geobacillus sp. WCH70
NCBI taxonomy Id: 471223
Other names: G. sp. WCH70
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