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thiC thiC ACS24671.1 ACS24671.1 thiG thiG ACS26021.1 ACS26021.1 ACS23507.1 ACS23507.1 thiE thiE ACS23506.1 ACS23506.1 purM purM ACS23298.1 ACS23298.1 purK purK ACS23509.1 ACS23509.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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Predicted Interactions
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textmining
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protein homology
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (573 aa)    
Predicted Functional Partners:
ACS24671.1
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: gka:GK1510 phosphomethylpyrimidine kinase.
  
 
 0.976
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.936
ACS26021.1
TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: gtn:GTNG_3383 pyridoxal kinase.
  
 
 0.880
ACS23507.1
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: gtn:GTNG_0537 sulfur carrier protein ThiS.
  
  
 0.845
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.827
ACS23506.1
PFAM: thiamine monophosphate synthase; KEGG: gtn:GTNG_0535 transcriptional regulator TenI.
 
  
 0.822
purM
Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: gka:GK0265 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein.
     
 0.811
ACS23298.1
Hypothetical protein.
       0.803
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
ACS23509.1
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: gka:GK0626 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein.
  
  
 0.774
Your Current Organism:
Geobacillus sp. WCH70
NCBI taxonomy Id: 471223
Other names: G. sp. WCH70
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