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gcvH gcvH gcvT gcvT gcvP gcvP lpd-2 lpd-2 lpd lpd lpd-3 lpd-3 lpd-4 lpd-4 glyA glyA lplA lplA Minf_1332 Minf_1332 Minf_0717 Minf_0717
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
gcvHGlycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system T protein (aminomethyltransferase).
 
 0.999
gcvP
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain; Belongs to the GcvP family.
 
 0.999
lpd-2
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme.
 
  
 0.978
lpd
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component.
 
  
 0.977
lpd-3
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme.
 
  
 0.977
lpd-4
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme.
 
  
 0.977
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
 
 
 0.974
lplA
Lipoate-protein ligase A.
 
 
 0.968
Minf_1332
Serine-pyruvate aminotransferase/aspartate aminotransferase.
   
 
 0.909
Minf_0717
Proline dehydrogenase and delta 1-pyrroline-5-carboxylate dehydrogenase.
    
 0.883
Your Current Organism:
Methylacidiphilum infernorum
NCBI taxonomy Id: 481448
Other names: M. infernorum V4, Methylacidiphilum infernorum V4, Methylacidiphilum infernorum str. V4, Methylacidiphilum infernorum strain V4, Verrucomicrobia bacterium V4, Verrucomicrobiae bacterium V4
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