node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPB3 | RPB5 | YIL021W | YBR154C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.999 |
RPB3 | RPB7 | YIL021W | YDR404C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB3 | RPB9 | YIL021W | YGL070C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.999 |
RPB3 | RPC10 | YIL021W | YHR143W-A | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | 0.999 |
RPB3 | RPO21 | YIL021W | YDL140C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB3 | RTR1 | YIL021W | YER139C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | RNA polymerase II subunit B1 CTD phosphatase RTR1; CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication; Belongs to the RPAP2 family. | 0.998 |
RPB3 | SPT4 | YIL021W | YGR063C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions. | 0.999 |
RPB3 | SRB4 | YIL021W | YER022W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination. | 0.999 |
RPB3 | TFG1 | YIL021W | YGR186W | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
RPB3 | TFG2 | YIL021W | YGR005C | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |
RPB5 | RPB3 | YBR154C | YIL021W | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
RPB5 | RPB7 | YBR154C | YDR404C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB5 | RPB9 | YBR154C | YGL070C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.999 |
RPB5 | RPC10 | YBR154C | YHR143W-A | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | 0.999 |
RPB5 | RPO21 | YBR154C | YDL140C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB5 | RTR1 | YBR154C | YER139C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | RNA polymerase II subunit B1 CTD phosphatase RTR1; CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication; Belongs to the RPAP2 family. | 0.998 |
RPB5 | SPT4 | YBR154C | YGR063C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions. | 0.999 |
RPB5 | SRB4 | YBR154C | YER022W | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination. | 0.994 |
RPB5 | TFG1 | YBR154C | YGR186W | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
RPB5 | TFG2 | YBR154C | YGR005C | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |