node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atoA | atoC | b2222 | b2220 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | 0.875 |
atoA | atoD | b2222 | b2221 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | 0.999 |
atoA | atoE | b2222 | b2223 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | 0.986 |
atoA | atoS | b2222 | b2219 | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | Sensory histidine kinase in two-component regulatory system with AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in response [...] | 0.663 |
atoC | atoA | b2220 | b2222 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | 0.875 |
atoC | atoD | b2220 | b2221 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | 0.888 |
atoC | atoE | b2220 | b2223 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | 0.612 |
atoC | atoS | b2220 | b2219 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Sensory histidine kinase in two-component regulatory system with AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in response [...] | 0.999 |
atoC | cheA | b2220 | b1888 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Chemotaxis protein CheA; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. | 0.608 |
atoC | fadR | b2220 | b1187 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Fatty acid metabolism regulon transcriptional regulator; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. | 0.808 |
atoC | fliM | b2220 | b1945 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Flagellar motor switching and energizing component; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. | 0.604 |
atoC | rcsC | b2220 | b2218 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC has also phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division. | 0.636 |
atoC | rpoN | b2220 | b3202 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | RNA polymerase, sigma 54 (sigma N) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). | 0.859 |
atoC | zraS | b2220 | b4003 | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. | 0.691 |
atoD | atoA | b2221 | b2222 | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | 0.999 |
atoD | atoC | b2221 | b2220 | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | 0.888 |
atoD | atoE | b2221 | b2223 | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | 0.982 |
atoD | atoS | b2221 | b2219 | acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation. | Sensory histidine kinase in two-component regulatory system with AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in response [...] | 0.633 |
atoE | atoA | b2223 | b2222 | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family. | 0.986 |
atoE | atoC | b2223 | b2220 | Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids. | Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] | 0.612 |