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aroC aroC aroA aroA aroB aroB aroE aroE trpE trpE ACR72302.1 ACR72302.1 ACR71749.1 ACR71749.1 ACR71405.1 ACR71405.1 aroK-2 aroK-2 ACR71693.1 ACR71693.1 tgt tgt
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.996
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.976
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.958
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 
 0.955
ACR72302.1
Anthranilate synthase component II; Psort-B: Cytoplasmic, score:8.87; COG0512 Anthranilate/para-aminobenzoate synthases component II; HMMPfam:IPR000991; FPrintScan:IPR001317; FPrintScan:IPR006220; FPrintScan:IPR011702; HMMTigr:IPR006221; ScanRegExp:IPR012998; K01658 anthranilate synthase component II.
 
 
 0.949
ACR71749.1
Putative pyruvate-flavodoxin oxidoreductase; Psort-B: Cytoplasmic, score:8.87; COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; HMMPfam:IPR001450; HMMPfam:IPR002869; HMMPfam:IPR002880; Gene3D:IPR015941; HMMPIR:IPR011895; HMMTigr:IPR011895; ScanRegExp:IPR001450; superfamily:IPR009014; K03737 putative pyruvate-flavodoxin oxidoreductase.
   
 
 0.910
ACR71405.1
Chorismate mutase; Psort-B: Unknown cell location; COG4492 ACT domain-containing protein; HMMPfam:IPR002912; HMMPIR:IPR008310; K06209 chorismate mutase; Belongs to the UPF0735 family.
     
  0.900
aroK-2
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.864
ACR71693.1
Prephenate dehydrogenase; Psort-B: Cytoplasmic, score:8.87; COG0287 Prephenate dehydrogenase; HMMPfam:IPR003099; HMMPanther:IPR003099; K00210 prephenate dehydrogenase.
  
 
 0.855
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...]
       0.794
Your Current Organism:
Eubacterium eligens
NCBI taxonomy Id: 515620
Other names: Eubacterium eligens ATCC 27750, [. eligens ATCC 27750, [Eubacterium] eligens ATCC 27750
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