node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PC1_1177 | PC1_1178 | PC1_1177 | PC1_1178 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: eca:ECA1300 D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | 0.532 |
PC1_1177 | PC1_3076 | PC1_1177 | PC1_3076 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | 0.510 |
PC1_1177 | PC1_3137 | PC1_1177 | PC1_3137 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | PFAM: Methyltransferase type 11; KEGG: eca:ECA3341 hypothetical protein. | 0.526 |
PC1_1177 | lipA | PC1_1177 | PC1_1175 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.502 |
PC1_1177 | lipB | PC1_1177 | PC1_1176 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.739 |
PC1_1177 | mutH | PC1_1177 | PC1_0903 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | DNA mismatch repair endonuclease mutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.503 |
PC1_1177 | proQ | PC1_1177 | PC1_1852 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.494 |
PC1_1177 | rraB | PC1_1177 | PC1_0375 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.519 |
PC1_1177 | seqA | PC1_1177 | PC1_1211 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.502 |
PC1_1177 | yihI | PC1_1177 | PC1_4225 | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.513 |
PC1_1178 | PC1_1177 | PC1_1178 | PC1_1177 | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: eca:ECA1300 D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | 0.532 |
PC1_3076 | PC1_1177 | PC1_3076 | PC1_1177 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | 0.510 |
PC1_3076 | PC1_3137 | PC1_3076 | PC1_3137 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | PFAM: Methyltransferase type 11; KEGG: eca:ECA3341 hypothetical protein. | 0.515 |
PC1_3076 | mutH | PC1_3076 | PC1_0903 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | DNA mismatch repair endonuclease mutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family. | 0.553 |
PC1_3076 | proQ | PC1_3076 | PC1_1852 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family. | 0.619 |
PC1_3076 | rraB | PC1_3076 | PC1_0375 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.674 |
PC1_3076 | seqA | PC1_3076 | PC1_1211 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.695 |
PC1_3076 | yihI | PC1_3076 | PC1_4225 | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | Protein of unknown function DUF414; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.663 |
PC1_3137 | PC1_1177 | PC1_3137 | PC1_1177 | PFAM: Methyltransferase type 11; KEGG: eca:ECA3341 hypothetical protein. | PFAM: protein of unknown function DUF493; KEGG: eca:ECA1299 hypothetical protein; Belongs to the UPF0250 family. | 0.526 |
PC1_3137 | PC1_3076 | PC1_3137 | PC1_3076 | PFAM: Methyltransferase type 11; KEGG: eca:ECA3341 hypothetical protein. | Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] | 0.515 |