node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | HDEF_0107 | HDEF_0108 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | 0.999 |
carA | fre | HDEF_0107 | HDEF_2108 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Flavin reductase; Preferred substrate is FAD; COG0543. | 0.917 |
carA | purF | HDEF_0107 | HDEF_0788 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Amidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.960 |
carA | purL | HDEF_0107 | HDEF_0875 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Phosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.945 |
carA | pyrB | HDEF_0107 | HDEF_1941 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Aspartate carbamoyltransferase, catalytic subunit; COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carA | pyrD | HDEF_0107 | HDEF_0655 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Dihydroorotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.927 |
carA | pyrE | HDEF_0107 | HDEF_0508 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.916 |
carA | pyrF | HDEF_0107 | HDEF_0114 | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.918 |
carB | carA | HDEF_0108 | HDEF_0107 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | 0.999 |
carB | fre | HDEF_0108 | HDEF_2108 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Flavin reductase; Preferred substrate is FAD; COG0543. | 0.928 |
carB | purF | HDEF_0108 | HDEF_0788 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Amidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.973 |
carB | purL | HDEF_0108 | HDEF_0875 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Phosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.639 |
carB | pyrB | HDEF_0108 | HDEF_1941 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Aspartate carbamoyltransferase, catalytic subunit; COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrD | HDEF_0108 | HDEF_0655 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Dihydroorotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.941 |
carB | pyrE | HDEF_0108 | HDEF_0508 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.942 |
carB | pyrF | HDEF_0108 | HDEF_0114 | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.937 |
fre | carA | HDEF_2108 | HDEF_0107 | Flavin reductase; Preferred substrate is FAD; COG0543. | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; COG0505; Belongs to the CarA family. | 0.917 |
fre | carB | HDEF_2108 | HDEF_0108 | Flavin reductase; Preferred substrate is FAD; COG0543. | Carbamoyl phosphate synthase, large subunit; COG0458; Belongs to the CarB family. | 0.928 |
fre | purL | HDEF_2108 | HDEF_0875 | Flavin reductase; Preferred substrate is FAD; COG0543. | Phosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.497 |
fre | pyrB | HDEF_2108 | HDEF_1941 | Flavin reductase; Preferred substrate is FAD; COG0543. | Aspartate carbamoyltransferase, catalytic subunit; COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.921 |