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pyrG pyrG guaA_C guaA_C ndk ndk rps2P rps2P dcd dcd argS argS nrdD nrdD valS valS rpl13P rpl13P rpl10E-1 rpl10E-1 rpoB rpoB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pyrGCTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)    
Predicted Functional Partners:
guaA_C
GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (C terminal domain) (guaA_C); Catalyzes the synthesis of GMP from XMP.
  
 
 0.952
ndk
Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.947
rps2P
SSU ribosomal protein S2P (rps2P); Belongs to the universal ribosomal protein uS2 family.
  
 
 0.942
dcd
Deoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP.
  
 
 0.932
argS
Arginyl-tRNA synthetase (argS); Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.921
nrdD
Anaerobic ribonucleoside triphosphate reductase (nrdD).
    
 0.915
valS
Valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
 
 
 0.865
rpl13P
LSU ribosomal protein L13P (rpl13P); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.855
rpl10E-1
LSU ribosomal protein L10E (rpl10E); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
   
 
 0.833
rpoB
DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.810
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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