node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0335 | queF | Tola_0335 | Tola_0493 | Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.732 |
Tola_0381 | Tola_0760 | Tola_0381 | Tola_0760 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | KEGG: ppr:PBPRB0335 hypothetical protein. | 0.770 |
Tola_0381 | queC | Tola_0381 | Tola_0948 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.609 |
Tola_0381 | queF | Tola_0381 | Tola_0493 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.812 |
Tola_0491 | Tola_0492 | Tola_0491 | Tola_0492 | PFAM: conserved hypothetical protein; KEGG: asa:ASA_3181 lysine decarboxylase family protein. | PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: asa:ASA_3179 hypothetical protein. | 0.661 |
Tola_0491 | queF | Tola_0491 | Tola_0493 | PFAM: conserved hypothetical protein; KEGG: asa:ASA_3181 lysine decarboxylase family protein. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.644 |
Tola_0491 | syd | Tola_0491 | Tola_0494 | PFAM: conserved hypothetical protein; KEGG: asa:ASA_3181 lysine decarboxylase family protein. | Syd family protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.424 |
Tola_0492 | Tola_0491 | Tola_0492 | Tola_0491 | PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: asa:ASA_3179 hypothetical protein. | PFAM: conserved hypothetical protein; KEGG: asa:ASA_3181 lysine decarboxylase family protein. | 0.661 |
Tola_0492 | queF | Tola_0492 | Tola_0493 | PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: asa:ASA_3179 hypothetical protein. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.613 |
Tola_0492 | syd | Tola_0492 | Tola_0494 | PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: asa:ASA_3179 hypothetical protein. | Syd family protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.487 |
Tola_0760 | Tola_0381 | Tola_0760 | Tola_0381 | KEGG: ppr:PBPRB0335 hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.770 |
Tola_0760 | queC | Tola_0760 | Tola_0948 | KEGG: ppr:PBPRB0335 hypothetical protein. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.857 |
Tola_0760 | queE | Tola_0760 | Tola_2496 | KEGG: ppr:PBPRB0335 hypothetical protein. | Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.808 |
Tola_0760 | queF | Tola_0760 | Tola_0493 | KEGG: ppr:PBPRB0335 hypothetical protein. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.833 |
Tola_0760 | tgt | Tola_0760 | Tola_2030 | KEGG: ppr:PBPRB0335 hypothetical protein. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.404 |
queA | queC | Tola_2031 | Tola_0948 | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.489 |
queA | queF | Tola_2031 | Tola_0493 | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.583 |
queA | tgt | Tola_2031 | Tola_2030 | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.988 |
queC | Tola_0381 | Tola_0948 | Tola_0381 | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.609 |
queC | Tola_0760 | Tola_0948 | Tola_0760 | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | KEGG: ppr:PBPRB0335 hypothetical protein. | 0.857 |