node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0349 | dnaA | Tola_0349 | Tola_0001 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: aha:AHA_0220 DNA helicase II. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.529 |
Tola_0349 | recF | Tola_0349 | Tola_0003 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: aha:AHA_0220 DNA helicase II. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.424 |
Tola_0349 | recR | Tola_0349 | Tola_2215 | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: aha:AHA_0220 DNA helicase II. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.610 |
Tola_1996 | Tola_2216 | Tola_1996 | Tola_2216 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: aha:AHA_1497 pyruvate:ferredoxin (flavodoxin) oxidoreductase. | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | 0.419 |
Tola_1996 | htpG | Tola_1996 | Tola_2214 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: aha:AHA_1497 pyruvate:ferredoxin (flavodoxin) oxidoreductase. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.403 |
Tola_1996 | recR | Tola_1996 | Tola_2215 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: aha:AHA_1497 pyruvate:ferredoxin (flavodoxin) oxidoreductase. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.617 |
Tola_2216 | Tola_1996 | Tola_2216 | Tola_1996 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: aha:AHA_1497 pyruvate:ferredoxin (flavodoxin) oxidoreductase. | 0.419 |
Tola_2216 | dnaX | Tola_2216 | Tola_2217 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.873 |
Tola_2216 | htpG | Tola_2216 | Tola_2214 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.543 |
Tola_2216 | recR | Tola_2216 | Tola_2215 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.976 |
Tola_3141 | dnaA | Tola_3141 | Tola_0001 | KEGG: aha:AHA_4270 chromosome partitioning protein ParB; TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; Belongs to the ParB family. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.719 |
Tola_3141 | recR | Tola_3141 | Tola_2215 | KEGG: aha:AHA_4270 chromosome partitioning protein ParB; TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; Belongs to the ParB family. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.630 |
Tola_3141 | xerC | Tola_3141 | Tola_3119 | KEGG: aha:AHA_4270 chromosome partitioning protein ParB; TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; Belongs to the ParB family. | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.577 |
dnaA | Tola_0349 | Tola_0001 | Tola_0349 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | TIGRFAM: DNA helicase II; PFAM: UvrD/REP helicase; KEGG: aha:AHA_0220 DNA helicase II. | 0.529 |
dnaA | Tola_3141 | Tola_0001 | Tola_3141 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | KEGG: aha:AHA_4270 chromosome partitioning protein ParB; TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; Belongs to the ParB family. | 0.719 |
dnaA | dnaX | Tola_0001 | Tola_2217 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.491 |
dnaA | recF | Tola_0001 | Tola_0003 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.939 |
dnaA | recR | Tola_0001 | Tola_2215 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.725 |
dnaA | xerC | Tola_0001 | Tola_3119 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.458 |
dnaX | Tola_2216 | Tola_2217 | Tola_2216 | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | 0.873 |