node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TSIB_0624 | TSIB_0625 | TSIB_0624 | TSIB_0625 | Hypothetical protein. | Hydrolase, HAD superfamily. | 0.726 |
TSIB_0624 | TSIB_0626 | TSIB_0624 | TSIB_0626 | Hypothetical protein. | Hypothetical protein. | 0.726 |
TSIB_0624 | cobB | TSIB_0624 | TSIB_0623 | Hypothetical protein. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.814 |
TSIB_0624 | glyA | TSIB_0624 | TSIB_0622 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.584 |
TSIB_0625 | TSIB_0624 | TSIB_0625 | TSIB_0624 | Hydrolase, HAD superfamily. | Hypothetical protein. | 0.726 |
TSIB_0625 | TSIB_0626 | TSIB_0625 | TSIB_0626 | Hydrolase, HAD superfamily. | Hypothetical protein. | 0.818 |
TSIB_0625 | cobB | TSIB_0625 | TSIB_0623 | Hydrolase, HAD superfamily. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.733 |
TSIB_0625 | glyA | TSIB_0625 | TSIB_0622 | Hydrolase, HAD superfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.536 |
TSIB_0626 | TSIB_0624 | TSIB_0626 | TSIB_0624 | Hypothetical protein. | Hypothetical protein. | 0.726 |
TSIB_0626 | TSIB_0625 | TSIB_0626 | TSIB_0625 | Hypothetical protein. | Hydrolase, HAD superfamily. | 0.818 |
TSIB_0626 | cobB | TSIB_0626 | TSIB_0623 | Hypothetical protein. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.723 |
TSIB_0626 | glyA | TSIB_0626 | TSIB_0622 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.516 |
TSIB_1082 | cobB | TSIB_1082 | TSIB_0623 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.955 |
TSIB_1082 | nadE | TSIB_1082 | TSIB_1759 | Nicotinamide-nucleotide adenylyltransferase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.955 |
TSIB_1082 | nadK | TSIB_1082 | TSIB_1840 | Nicotinamide-nucleotide adenylyltransferase. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.923 |
TSIB_1110 | cobB | TSIB_1110 | TSIB_0623 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.976 |
TSIB_1110 | glyA | TSIB_1110 | TSIB_0622 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.497 |
TSIB_1670 | cobB | TSIB_1670 | TSIB_0623 | Pyrazinamidase/nicotinamidase pxnc. | NAD-dependent deacetylase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. | 0.935 |
TSIB_1670 | nadE | TSIB_1670 | TSIB_1759 | Pyrazinamidase/nicotinamidase pxnc. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.589 |
TSIB_1670 | nadK | TSIB_1670 | TSIB_1840 | Pyrazinamidase/nicotinamidase pxnc. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.423 |