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tet(56) tet(56) LLO_0722 LLO_0722 LLO_0975 LLO_0975 LLO_2214 LLO_2214 LLO_3443 LLO_3443 LLO_0976 LLO_0976 LLO_0433 LLO_0433 LLO_0737 LLO_0737 LLO_0978 LLO_0978 LLO_2224 LLO_2224 rkpA rkpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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tet(56)Hypothetical protein (truncated); An FAD-requiring monooxygenase active on tetracycline antibiotic and some of its derivatives, which leads to their inactivation. Expression in E.coli confers high resistance to tetracycline and oxytetracycline, does not confer resistance to minocycline or tigecycline. The reaction requires NADPH. Expression in L.pneumophila confers resistance to tetracycline. Degrades and confers resistance to tetracycline and chlortetracycline. (389 aa)    
Predicted Functional Partners:
LLO_0722
Putative polyketide synthase of type I; Equals llo0722.
 
 
 0.779
LLO_0975
Putative non-ribosomal peptide synthetase/polyketide synthetase; Equals llo0975.
  
 
 0.769
LLO_2214
Equals llo2214; similar to FAD monooxygenase, PheA/TfdB family.
  
   
 0.718
LLO_3443
Putative polyketide synthase; Equals llo3443; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.666
LLO_0976
Putative non-ribosomal peptide synthase; Equals llo0976.
  
 
 0.642
LLO_0433
Putative prolyl oligopeptidase; Equals llo0433.
  
     0.638
LLO_0737
Putative monooxygenase, FAD-binding; Equals llo0737.
  
     0.621
LLO_0978
Putative luciferase-like monooxygenase; Equals llo0978.
  
 
 0.614
LLO_2224
Putative pyoverdine biosynthesis protein; Equals llo2224.
  
     0.606
rkpA
Putative type I polyketide synthase WcbR; Equals llo3179.
 
 
 0.589
Your Current Organism:
Legionella longbeachae
NCBI taxonomy Id: 661367
Other names: L. longbeachae NSW150, Legionella longbeachae NSW150, Legionella longbeachae str. NSW150, Legionella longbeachae strain NSW150
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