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eya eya so so dac dac Optix Optix Six4 Six4 sv sv ato ato Fas3 Fas3 eyg eyg zfh1 zfh1 tsh tsh
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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textmining
co-expression
protein homology
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eyaDevelopmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family. (766 aa)    
Predicted Functional Partners:
so
Sine oculis (so) encodes a homeobox-containing transcription factor that functions with the product of eya as a transcriptional co-activator. It contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis.
   
 
 0.999
dac
Dachshund, isoform B; Dachshund (dac) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by eya and so, and regulates eye, leg, gonad, and brain development.
   
 
 0.994
Optix
Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement.
   
 
 0.986
Six4
Homeobox protein SIX4; Six4 (Six4) encodes a homeodomain-containing transcription factor required for mesodermal patterning to form the embryonic gonad.
   
 
 0.969
sv
Shaven, isoform A; Shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye.
      
 0.856
ato
Protein atonal; Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection.
   
  
 0.850
Fas3
Fasciclin-3; Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system.
   
  
 0.842
eyg
Eyegone, isoform A; Eyegone (eyg) encodes a Pax family transcription factor that acts as a transcriptional repressor. In eye development, the product of eyg promotes cell proliferation in the larval eye disc through activation of Jak/STAT pathway. It also plays both positive and negative roles in head vortex development.
   
 
 0.841
zfh1
Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
      
 0.839
tsh
Protein teashirt; Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk. Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity. Necessary, in combination with Scr, for the formation of the prothoracic segment. Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes. Required for pr [...]
   
  
 0.818
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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