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Cyp12d1-p Cyp12d1-p Lcp1 Lcp1 Cyp6g1 Cyp6g1 Cyp9f3 Cyp9f3 Mdr65 Mdr65 Cyp6a2 Cyp6a2 Cyp6a8 Cyp6a8 CG2065 CG2065 Mdr50 Mdr50 Cyp6d5 Cyp6d5 MRP MRP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
Cyp12d1-pProbable cytochrome P450 12d1 proximal, mitochondrial; Cyp12d1-p (Cyp12d1-p) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). (521 aa)    
Predicted Functional Partners:
Lcp1
Larval cuticle protein 1; Component of the larval cuticle.
    
 
 0.607
Cyp6g1
Cytochrome P450 6g1; Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones.
  
 
0.570
Cyp9f3
Cyp9f3; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; monooxygenase activity. It is involved in the biological process described with: oxidation-reduction process.
  
 
 0.565
Mdr65
Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
   
  
 0.550
Cyp6a2
Cytochrome P450 6a2; Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones.
  
 
0.550
Cyp6a8
Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.546
CG2065
RH23455p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.528
Mdr50
Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion.
   
  
 0.526
Cyp6d5
Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.524
MRP
Multidrug-Resistance like protein 1, isoform A; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase-coupled inorganic anion transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; renal tubular secretion; response to toxic substance; anion transmembrane transport.
   
 
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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