node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG42374 | CG5181 | FBpp0310827 | FBpp0079091 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | SOSS complex subunit B homolog; DNA binding; single-stranded DNA binding. It is involved in the biological process described with: DNA repair; mitotic cell cycle checkpoint; response to ionizing radiation; double-strand break repair via homologous recombination; Belongs to the SOSS-B family. | 0.955 |
CG42374 | IntS3 | FBpp0310827 | FBpp0110478 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | 0.992 |
CG42374 | Rbbp5 | FBpp0310827 | FBpp0077900 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | 0.646 |
CG42374 | mtSSB | FBpp0310827 | FBpp0082729 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase tam at the replication fork. Promotes tam activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate tam activity. | 0.524 |
CG42374 | pho | FBpp0310827 | FBpp0088268 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] | 0.544 |
CG42374 | pum | FBpp0310827 | FBpp0305823 | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] | 0.422 |
CG5181 | CG42374 | FBpp0079091 | FBpp0310827 | SOSS complex subunit B homolog; DNA binding; single-stranded DNA binding. It is involved in the biological process described with: DNA repair; mitotic cell cycle checkpoint; response to ionizing radiation; double-strand break repair via homologous recombination; Belongs to the SOSS-B family. | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.955 |
CG5181 | IntS3 | FBpp0079091 | FBpp0110478 | SOSS complex subunit B homolog; DNA binding; single-stranded DNA binding. It is involved in the biological process described with: DNA repair; mitotic cell cycle checkpoint; response to ionizing radiation; double-strand break repair via homologous recombination; Belongs to the SOSS-B family. | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | 0.954 |
IntS3 | CG42374 | FBpp0110478 | FBpp0310827 | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.992 |
IntS3 | CG5181 | FBpp0110478 | FBpp0079091 | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | SOSS complex subunit B homolog; DNA binding; single-stranded DNA binding. It is involved in the biological process described with: DNA repair; mitotic cell cycle checkpoint; response to ionizing radiation; double-strand break repair via homologous recombination; Belongs to the SOSS-B family. | 0.954 |
IntS3 | mtSSB | FBpp0110478 | FBpp0082729 | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase tam at the replication fork. Promotes tam activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate tam activity. | 0.496 |
Rbbp5 | CG42374 | FBpp0077900 | FBpp0310827 | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.646 |
mtSSB | CG42374 | FBpp0082729 | FBpp0310827 | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase tam at the replication fork. Promotes tam activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate tam activity. | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.524 |
mtSSB | IntS3 | FBpp0082729 | FBpp0110478 | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase tam at the replication fork. Promotes tam activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate tam activity. | Integrator complex subunit 3; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. However this subunit is not essential for the 3'-end processing of the snRNA U7 and the spliceosomal snRNAs U1, U2, U4 and U5. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). | 0.496 |
pho | CG42374 | FBpp0088268 | FBpp0310827 | Polycomb protein PHO; Polycomb group (PcG) protein that binds to the 5'- CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but no [...] | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.544 |
pum | CG42374 | FBpp0305823 | FBpp0310827 | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] | SOSS complex subunit C homolog; It is involved in the biological process described with: DNA repair; Belongs to the SOSS-C family. | 0.422 |