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arih1 arih1 rbx1 rbx1 ube2l3b ube2l3b ube2l3a ube2l3a nedd8 nedd8 nedd8l nedd8l eif2b5 eif2b5 cul1b cul1b rps27a rps27a cul3a cul3a cul3b cul3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
arih1E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...] (527 aa)    
Predicted Functional Partners:
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 
 0.932
ube2l3b
Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.849
ube2l3a
Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.848
nedd8
NEDD8 ubiquitin-like modifier.
    
 
 0.835
nedd8l
NEDD8 ubiquitin-like modifier, like.
    
 
 0.835
eif2b5
Eukaryotic translation initiation factor 2B, subunit 5 epsilon.
 
      0.823
cul1b
Cullin 1b; Belongs to the cullin family.
   
 
 0.809
rps27a
Ribosomal protein S27a.
    
 
 0.801
cul3a
Cullin 3a; Belongs to the cullin family.
   
 
 0.782
cul3b
Cullin 3b; Belongs to the cullin family.
   
 
 0.781
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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