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pi4k2a pi4k2a pi4kb pi4kb pi4kaa pi4kaa pikfyve pikfyve pik3c3 pik3c3 cdipt cdipt synj1 synj1 pik3r2 pik3r2 inpp5b inpp5b sacm1lb sacm1lb sacm1la sacm1la
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
pi4k2aPhosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). (447 aa)    
Predicted Functional Partners:
pi4kb
Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).
   
 0.992
pi4kaa
Phosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family.
    
 0.987
pikfyve
Phosphatidylinositol phosphate 5-kinase type III isoform d.
   
 
 0.947
pik3c3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
     
 0.943
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
   
 
 0.941
synj1
Synaptojanin 1.
     
 0.936
pik3r2
Phosphoinositide-3-kinase, regulatory subunit 2 (beta).
     
 0.931
inpp5b
Inositol polyphosphate-5-phosphatase B.
     
 0.927
sacm1lb
Phosphatidylinositide phosphatase SAC1-B; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).
     
 0.925
sacm1la
Phosphatidylinositide phosphatase SAC1-A; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).
     
 0.925
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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