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zfyve28 zfyve28 eps8l3b eps8l3b jph1a jph1a pik3r3b pik3r3b exd3 exd3 SH3RF3 SH3RF3 si:dkey-97o5.1 si:dkey-97o5.1 ush1c ush1c sdf4 sdf4 col5a3a col5a3a il6r il6r
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
zfyve28Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family. (975 aa)    
Predicted Functional Partners:
eps8l3b
EPS8-like 3b.
      
 0.837
jph1a
Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
   
  
 0.721
pik3r3b
Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma).
      
 0.644
exd3
Exonuclease 3'-5' domain-containing 3.
      
 0.592
SH3RF3
Si:ch211-124n19.2.
      
 0.574
si:dkey-97o5.1
Uncharacterized protein C1orf112 homolog.
      
 0.557
ush1c
Usher syndrome 1C (Autosomal recessive, severe).
      
 0.542
sdf4
45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family.
   
  
 0.485
col5a3a
Collagen, type V, alpha 3a.
      
 0.480
il6r
Interleukin 6 receptor.
      
 0.479
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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