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jag1a jag1a notch1a notch1a notch1b notch1b notch3 notch3 notch2 notch2 hey1 hey1 jag2b jag2b jag1b jag1b rbpja rbpja hey2 hey2 maml1 maml1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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jag1aProtein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa)    
Predicted Functional Partners:
notch1a
Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]
   
0.999
notch1b
Notch receptor 1b.
   
0.987
notch3
Notch receptor 3.
   
0.985
notch2
Notch receptor 2.
   
0.983
hey1
Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which functions as a downstream effector of Notch signaling; Belongs to the HEY family.
    
 
 0.938
jag2b
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
  
 
0.910
jag1b
Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
  
 
0.908
rbpja
Recombination signal-binding protein for immunoglobulin kappa J region a.
    
 
 0.897
hey2
Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family.
    
 
 0.869
maml1
Mastermind-like transcriptional coactivator 1.
    
 
 0.848
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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