node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carD | rpoA | Rv3583c | Rv3457c | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.982 |
carD | rpoB | Rv3583c | Rv0667 | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
carD | rpoC | Rv3583c | Rv0668 | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.990 |
carD | rpoZ | Rv3583c | Rv1390 | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.976 |
carD | sigA | Rv3583c | Rv2703 | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | RNA polymerase sigma factor SigA (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable); Belongs to the sigma-70 factor family. RpoD/SigA subfamily. | 0.974 |
carD | sigB | Rv3583c | Rv2710 | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. A non-essential principal sigma factor that responds to cell envelope stress and hypoxia. Controls a regulon of about 40 genes, with another 100 genes expression being altered during SDS stress and about 50 gene being altered during diamide (oxidative) stress. | 0.802 |
rplC | rplK | Rv0701 | Rv0640 | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.999 |
rplC | rpoA | Rv0701 | Rv3457c | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.997 |
rplC | rpoB | Rv0701 | Rv0667 | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
rplC | rpoC | Rv0701 | Rv0668 | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.958 |
rplC | rpoZ | Rv0701 | Rv1390 | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.683 |
rplK | rplC | Rv0640 | Rv0701 | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.999 |
rplK | rpoA | Rv0640 | Rv3457c | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.994 |
rplK | rpoB | Rv0640 | Rv0667 | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.998 |
rplK | rpoC | Rv0640 | Rv0668 | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.973 |
rplK | rpoZ | Rv0640 | Rv1390 | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.838 |
rpoA | carD | Rv3457c | Rv3583c | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Possible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family. | 0.982 |
rpoA | rplC | Rv3457c | Rv0701 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 50S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.997 |
rpoA | rplK | Rv3457c | Rv0640 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 50S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.994 |
rpoA | rpoB | Rv3457c | Rv0667 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |