node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1496 | mazE4 | Rv1496 | Rv1494 | Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | 0.803 |
Rv1496 | mazF4 | Rv1496 | Rv1495 | Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. Belongs to the PemK/MazF family. | 0.803 |
Rv1496 | mutA | Rv1496 | Rv1492 | Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Probable methylmalonyl-CoA mutase small subunit MutA (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates; Belongs to the methylmalonyl-CoA mutase family. | 0.982 |
Rv1496 | mutB | Rv1496 | Rv1493 | Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | 0.996 |
fadD25 | mazE4 | Rv1521 | Rv1494 | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | 0.803 |
fadD25 | mazF4 | Rv1521 | Rv1495 | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. Belongs to the PemK/MazF family. | 0.720 |
fadD25 | mutA | Rv1521 | Rv1492 | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | Probable methylmalonyl-CoA mutase small subunit MutA (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates; Belongs to the methylmalonyl-CoA mutase family. | 0.513 |
fadD25 | mutB | Rv1521 | Rv1493 | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | 0.655 |
mazE4 | Rv1496 | Rv1494 | Rv1496 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | 0.803 |
mazE4 | fadD25 | Rv1494 | Rv1521 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4% identity in 584 aa overlap); NP_301232.1|NC_002677 acyl-CoA synthetase from Mycobacterium leprae (579 aa); etc. Also highly similar to others from Mycobacterium tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc. | 0.803 |
mazE4 | mazE5 | Rv1494 | Rv1943c | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | 0.635 |
mazE4 | mazE7 | Rv1494 | Rv2063 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.652 |
mazE4 | mazF4 | Rv1494 | Rv1495 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. Belongs to the PemK/MazF family. | 0.999 |
mazE4 | mutA | Rv1494 | Rv1492 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Probable methylmalonyl-CoA mutase small subunit MutA (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates; Belongs to the methylmalonyl-CoA mutase family. | 0.775 |
mazE4 | mutB | Rv1494 | Rv1493 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. | 0.840 |
mazE4 | purU | Rv1494 | Rv2964 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.789 |
mazE4 | vapB18 | Rv1494 | Rv2545 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Possible antitoxin VapB18; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC18. | 0.656 |
mazE4 | vapC32 | Rv1494 | Rv1114 | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | Possible toxin VapC32. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB32.; Belongs to the PINc/VapC protein family. | 0.654 |
mazE5 | mazE4 | Rv1943c | Rv1494 | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | 0.635 |
mazE5 | mazE7 | Rv1943c | Rv2063 | Possible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5. | Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7. | 0.760 |