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glbN glbN glbO glbO Rv0385 Rv0385 Rv2219A Rv2219A Rv1543 Rv1543 lprI lprI narK3 narK3 Rv1360 Rv1360 Rv2180c Rv2180c PPE21 PPE21 Rv1544 Rv1544
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glbNHemoglobin GlbN; Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate; Belongs to the truncated hemoglobin family. Group I subfamily. (136 aa)    
Predicted Functional Partners:
glbO
Globin (oxygen-binding protein) GlbO; When expressed in E.coli and M.smegmatis, HbO increases oxygen uptake. Membrane vesicles of E.coli carrying HbO show a respiration activity about twice that of membranes without HbO. HbO seems to interact with a terminal oxidase. Therefore, HbO could participate in oxygen/electron-transfer process, suggesting a function related to the facilitation of oxygen transfer during aerobic metabolism of M.tuberculosis.
   
  
 0.965
Rv0385
Rv0385, (MTV036.20), len: 390 aa. Probable monooxygenase, similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-termini) to various monooxygenases e.g. P19734|DMPP_PSESP|94993|F37831 phenol hydroxylase P5 protein (phenol 2-monooxygenase P5 component) from Pseudomonas putida (353 aa), FASTA scores: opt: 363, E(): 4.2e-16, (31.8% identity in 255 aa overlap); S47292|2120861|pir|S70085 phenol 2-monooxygenase chain mopP from Acinetobacter calcoaceticus (350 aa); P21394|XYLA_PSEPU|94933|B37316 xylene monooxygenas [...]
  
  
 0.884
Rv2219A
Rv2219A, len: 140 aa. Probable conserved membrane protein, similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa),FASTA scores: opt: 327, E(): 7.5e-14, (46.6% identity in 133 aa overlap), also linked to glnA.
   
  
 0.776
Rv1543
Rv1543, (MTCY48.22c), len: 341 aa. Possible fatty-acyl CoA reductase, highly similar to P94129|U77680 fatty acyl-CoA reductase ACR1 from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0,(48.5% identity in 293 aa overlap). Also highly similar to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty acyl-CoA reductase from Mycobacterium tuberculosis (650 aa). Also highly similar to many oxidoreductases short-chain family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
 0.699
lprI
Possible lipoprotein LprI; Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI; In the C [...]
  
  
 0.697
narK3
Rv0261c, (MTCY06A4.05c), len: 469 aa. Probable nirK3, nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 [...]
  
  
 0.666
Rv1360
Rv1360, (MTCY02B10.24), len: 340 aa. Probable oxidoreductase. Similar to Q49598|G1002714 coenzyme F420-dependent n5, n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 aa), FASTA scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa overlap).
  
  
 0.663
Rv2180c
Rv2180c, (MTV021.13c), len: 295 aa. Probable conserved integral membrane protein, similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1| (AL096872) (246 aa) (36% identity in 249 aa overlap).
      
 0.659
PPE21
Rv1548c, (MTCY48.17), len: 678 aa. PPE21, Member of the Mycobacterium tuberculosis PPE family, similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein in hsp65 3' region (517 aa), FASTA scores: opt:1142, E(): 0, (40.6% identity in 616 aa overlap); also similar to MTCY31.06c (54.9% identity in 381 aa overlap). Predicted to be an outer membrane protein (See Song et al.,2008).
   
  
 0.654
Rv1544
Rv1544, (MTCY48.21), len: 267 aa. Possible ketoacyl reductase, highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa), FASTA score: (43.0% identity in 270 aa overlap). Also highly similar to others e.g. T29125 ketoacyl reductase homolog from Streptomyces coelicolor (276 aa); NP_470957.1|NC_003212 protein similar to ketoacyl reductases from Listeria innocua (253 aa); HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp. strain PCC 7120 (287 aa), FASTA scores: opt: 379, E(): 7.5e-18, (31.6% identity in 250 aa overlap); etc. And highly similar to m [...]
  
    0.540
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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