node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1359 | Rv1674c | Rv1359 | Rv1674c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | 0.850 |
Rv1359 | Rv1931c | Rv1359 | Rv1931c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein; Controls the expression of genes important for virulence. | 0.855 |
Rv1359 | Rv2282c | Rv1359 | Rv2282c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Rv2282c, (MTCY339.28), len: 312 aa. Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): 4e-12, (27.6% identity in 286 aa overlap); etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis, FASTA score: (25.4% identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins,lysR family signature, and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD). | 0.803 |
Rv1359 | Rv2488c | Rv1359 | Rv2488c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Rv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory protein [...] | 0.846 |
Rv1359 | Rv3736 | Rv1359 | Rv3736 | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Transcriptional regulatory protein (probably AraC/XylS-family); Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 hypothetical 35.4 KDA protein from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 probable transcriptional regulator from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 probable transcriptional regulator from P [...] | 0.846 |
Rv1359 | cmr | Rv1359 | Rv1675c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.898 |
Rv1359 | embR | Rv1359 | Rv1267c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory family. | 0.833 |
Rv1359 | mftR | Rv1359 | Rv0691c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Probable transcriptional regulatory protein; May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier. | 0.860 |
Rv1359 | sigI | Rv1359 | Rv1189 | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). | 0.821 |
Rv1359 | tcrA | Rv1359 | Rv0602c | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | Two component DNA binding transcriptional regulatory protein TcrA; Member of the three-protein two-component system HK1/HK2/TcrA. | 0.858 |
Rv1674c | Rv1359 | Rv1674c | Rv1359 | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa overlap); To class-3 of adenylyl cyclases. | 0.850 |
Rv1674c | Rv1931c | Rv1674c | Rv1931c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Probable transcriptional regulatory protein; Controls the expression of genes important for virulence. | 0.864 |
Rv1674c | Rv2282c | Rv1674c | Rv2282c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Rv2282c, (MTCY339.28), len: 312 aa. Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: opt: 292, E(): 4e-12, (27.6% identity in 286 aa overlap); etc. Also similar to Rv0377|MTCY39.34 from Mycobacterium tuberculosis, FASTA score: (25.4% identity in 268 aa overlap). Contains PS00044 Bacterial regulatory proteins,lysR family signature, and contains helix-turn-helix motif at aa 24 -45 (+4.93 SD). | 0.848 |
Rv1674c | Rv2488c | Rv1674c | Rv2488c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Rv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093 aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv (1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75% identity in 1089 aa overlap); AAK45665|MT1402 from strain CDC1551 (1159 aa), FASTA scores: opt: 3395, E(): 8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also similar to transcriptional regulatory protein [...] | 0.827 |
Rv1674c | Rv3736 | Rv1674c | Rv3736 | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Transcriptional regulatory protein (probably AraC/XylS-family); Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators and hypothetical proteins e.g. CAC38740 hypothetical 35.4 KDA protein from Bradyrhizobium japonicum (318 aa), FASTA scores: opt: 438,E(): 2e-20, (29.4% identity in 306 aa overlap); Q9HZ25|PA3215 probable transcriptional regulator from Pseudomonas aeruginosa (337 aa), FASTA scores: opt: 395,E(): 1.1e-17, (30.3% identity in 320 aa overlap); Q9HTN1|PA5324 probable transcriptional regulator from P [...] | 0.859 |
Rv1674c | cmr | Rv1674c | Rv1675c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Probable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. | 0.918 |
Rv1674c | embR | Rv1674c | Rv1267c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Probable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory family. | 0.860 |
Rv1674c | mftR | Rv1674c | Rv0691c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Probable transcriptional regulatory protein; May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier. | 0.863 |
Rv1674c | sigI | Rv1674c | Rv1189 | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). | 0.821 |
Rv1674c | tcrA | Rv1674c | Rv0602c | Rv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa overlap). Similar to Rv0324|Z96800|MTCY63.29 M. tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E(): 0, (45.3% identity in 214 aa overlap). N-terminus is similar to transcriptional activators e.g. MERR_STRLI|P30346 probable mercury resistance operon regulator (125 aa), FASTA scores: opt: 183, E(): 1.9e-06,(35.6% identity in 90 aa overlap). Contains PS00380 Rhodanese signature 1. | Two component DNA binding transcriptional regulatory protein TcrA; Member of the three-protein two-component system HK1/HK2/TcrA. | 0.823 |