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PPE24 PPE24 PE_PGRS16 PE_PGRS16 Rv2293c Rv2293c Rv2082 Rv2082 cpnT cpnT Rv1004c Rv1004c PE_PGRS2 PE_PGRS2 PE_PGRS23 PE_PGRS23 PE_PGRS28 PE_PGRS28 PE_PGRS30 PE_PGRS30 Rv2209 Rv2209
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
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[Homology]
Score
PPE24Rv1753c, (MTCY28.16c), len: 1053 aa. PPE24, Member of the Mycobacterium tuberculosis PPE family of Gly-,Asn-rich proteins, similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa), FASTA scores: opt: 1360, E(): 0, (48.9% identity in 550 aa overlap). Note that the Gly-, Asn-rich sequence is interrupted by six near-perfect 26 aa repeats, a unique region, and another,more degenerate region of five 25 aa repeats before resuming at the C-terminus. The end of the first Gly-, Asn-rich region and the start of the first set of repeats shows some similarity to Q50577|AT10S fr [...] (1053 aa)    
Predicted Functional Partners:
PE_PGRS16
PE-PGRS family protein PE_PGRS16; Rv0977, (MTV044.05), len: 923 aa. PE_PGRS16, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to other PGRS-type sequences e.g. AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa), FASTA score: (45.4% identity in 959 aa overlap); Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa), FASTA score: (51.5% identity in 750 aa overlap); etc.
  
   
 0.828
Rv2293c
Rv2293c, (MTCY339.17), len: 246 aa. Conserved hypothetical protein; some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescentus] (33% identity in 131 aa overlap). Possible lipoprotein: signal peptide at N-terminus.
  
    0.777
Rv2082
Rv2082, (MTCY49.21), len: 721 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029, and to Rv3899c and Rv3900c which may be frameshifted.
  
    0.776
cpnT
Hypothetical alanine and proline rich protein; Has a dual function in uptake of nutrients and induction of host cell death. The N-terminal domain (NTD) forms an outer membrane channel and is used for uptake of nutrients across the outer membrane. The secreted C-terminal toxic domain (TNT) acts as a glycohydrolase, which hydrolyzes the essential cellular coenzyme NAD(+) in the cytosol of infected macrophages, leading to necrotic host cell death. Both functions are required for survival, replication and cytotoxicity of M.tuberculosis in macrophages.
 
   0.775
Rv1004c
Probable membrane protein; Rv1004c, (MTCI237.20c), len: 419 aa. Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequence.
  
     0.774
PE_PGRS2
PE-PGRS family protein PE_PGRS2; Rv0124, (MTCI418B.06), len: 487 aa. PE_PGRS2, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 2002), highly similar to many e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1730, E(): 0,(60.7% identity in 504 aa overlap).
  
     0.773
PE_PGRS23
PE-PGRS family protein PE_PGRS23; Rv1243c, (MTV006.15c), len: 562 aa. PE_PGRS23,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002).
  
     0.773
PE_PGRS28
PE-PGRS family protein PE_PGRS28; Rv1452c, (MTCY493.02), len: 741 aa. PE_PGRS28,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu,2002), similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% identity in 641 aa overlap).
  
     0.773
PE_PGRS30
PE-PGRS family protein PE_PGRS30; Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response. Required for full virulence. Involved in inhibition of phago-lysosome fusion.
  
     0.773
Rv2209
Rv2209, (MTCY190.20), len: 512 aa. Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e-32; 33.4% identity in 422 aa overlap.
  
    0.773
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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