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mbcT mbcT mbcA mbcA Rv3188 Rv3188 Rv0060 Rv0060 Rv3189 Rv3189 Rv1044 Rv1044 Rv0918 Rv0918 Rv0059 Rv0059 nrdF1 nrdF1 Rv3698 Rv3698 Rv2035 Rv2035
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mbcTHypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death. In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer. Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combi [...] (186 aa)    
Predicted Functional Partners:
mbcA
Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site.
  
 
 0.999
Rv3188
Conserved hypothetical protein; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin Rv3189 by blocking access to the toxin active site.
  
 
 0.985
Rv0060
Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein.
   
  
 0.660
Rv3189
Conserved hypothetical protein; Probable toxic component of a type II toxin-antitoxin (TA) system. Degrades NAD(+) by phosphorolysis. Neutralized by its cognate antitoxin Rv3188.
   
  
 0.658
Rv1044
Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in 150 aa overlap). Some similarity to U36837|LLU36837_1 Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores: opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
   
  
 0.653
Rv0918
Conserved protein; Rv0918, (MTCY21C12.12), len: 158 aa. Conserved protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132,E(): 0.0055, (65.6% identity in 32 aa overlap). Also some similarity in C-terminus with other hypothetical proteins e.g. NP_289961.1|NC_002655 hypothetical protein from Escherichia coli strain O157:H7 (94 aa); etc.
   
  
 0.652
Rv0059
Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein.
      
 0.651
nrdF1
Ribonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement; Belongs to the ribonucleoside diphosphate reductase small chain family.
   
  
 0.632
Rv3698
Conserved protein; Rv3698, (MTV025.046), len: 509 aa. Conserved protein, highly similar to Q9AK89|SC10A9.15c conserved hypothetical protein from Streptomyces coelicolor (505 aa),FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 conserved hypothetical protein (fragment) from Streptomyces coelicolor (291 aa), FASTA scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa overlap); and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt: 911,E(): 3.8e-51, (57.25% identity in 234 a [...]
   
  
 0.626
Rv2035
Rv2035, (MTV018.22), len: 162 aa. Conserved hypothetical protein, similar to many. Contains IPR013538 Activator of Hsp90 ATPase homologue 1-like.
   
  
 0.546
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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