node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2073c | Rv2074 | Rv2073c | Rv2074 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | 0.803 |
Rv2073c | Rv3789 | Rv2073c | Rv3789 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | 0.735 |
Rv2073c | cobK | Rv2073c | Rv2070c | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.805 |
Rv2073c | cobL | Rv2073c | Rv2072c | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.943 |
Rv2073c | cobM | Rv2073c | Rv2071c | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.805 |
Rv2073c | dprE1 | Rv2073c | Rv3790 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...] | 0.787 |
Rv2073c | embB | Rv2073c | Rv3795 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.406 |
Rv2073c | embC | Rv2073c | Rv3793 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.414 |
Rv2073c | ubiA | Rv2073c | Rv3806c | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Decaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Belongs to the UbiA prenyltransferase family. | 0.794 |
Rv2074 | Rv2073c | Rv2074 | Rv2073c | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.803 |
Rv2074 | cobK | Rv2074 | Rv2070c | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.764 |
Rv2074 | cobL | Rv2074 | Rv2072c | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.731 |
Rv2074 | cobM | Rv2074 | Rv2071c | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.732 |
Rv3789 | Rv2073c | Rv3789 | Rv2073c | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.735 |
Rv3789 | dprE1 | Rv3789 | Rv3790 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...] | 0.965 |
Rv3789 | embB | Rv3789 | Rv3795 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.874 |
Rv3789 | embC | Rv3789 | Rv3793 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.964 |
Rv3789 | ubiA | Rv3789 | Rv3806c | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Decaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Belongs to the UbiA prenyltransferase family. | 0.798 |
cobK | Rv2073c | Rv2070c | Rv2073c | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.805 |
cobK | Rv2074 | Rv2070c | Rv2074 | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. | 0.764 |