node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE23 | alaS | Rv2328 | Rv2555c | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.848 |
PE23 | cyp128 | Rv2328 | Rv2268c | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.493 |
PE23 | rpoA | Rv2328 | Rv3457c | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.747 |
PE23 | rpoB | Rv2328 | Rv0667 | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.724 |
PE23 | rpoZ | Rv2328 | Rv1390 | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.720 |
PE23 | stf3 | Rv2328 | Rv2267c | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.817 |
Rv2269c | cyp128 | Rv2269c | Rv2268c | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.968 |
Rv2269c | stf3 | Rv2269c | Rv2267c | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.968 |
alaS | PE23 | Rv2555c | Rv2328 | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | 0.848 |
alaS | rpoA | Rv2555c | Rv3457c | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.483 |
alaS | rpoB | Rv2555c | Rv0667 | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.573 |
alaS | stf3 | Rv2555c | Rv2267c | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.925 |
cyp128 | PE23 | Rv2268c | Rv2328 | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | 0.493 |
cyp128 | Rv2269c | Rv2268c | Rv2269c | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.968 |
cyp128 | stf3 | Rv2268c | Rv2267c | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.998 |
glnB | stf3 | Rv2919c | Rv2267c | Probable nitrogen regulatory protein P-II GlnB; In nitrogen-limiting conditions, when the ratio of Gln to 2- ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By si [...] | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.806 |
htpG | stf3 | Rv2299c | Rv2267c | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.933 |
mftF | stf3 | Rv0696 | Rv2267c | Probable membrane sugar transferase; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the glycosyltransferase 2 family. | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.823 |
rpoA | PE23 | Rv3457c | Rv2328 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum (638 aa), FASTA scores: opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa overlap); etc. | 0.747 |
rpoA | alaS | Rv3457c | Rv2555c | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.483 |