node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2073c | Rv3789 | Rv2073c | Rv3789 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | 0.735 |
Rv2073c | dprE1 | Rv2073c | Rv3790 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...] | 0.787 |
Rv2073c | embB | Rv2073c | Rv3795 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.406 |
Rv2073c | embC | Rv2073c | Rv3793 | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.414 |
Rv2073c | ubiA | Rv2073c | Rv3806c | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Decaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Belongs to the UbiA prenyltransferase family. | 0.794 |
Rv3789 | Rv2073c | Rv3789 | Rv2073c | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.735 |
Rv3789 | Rv3807c | Rv3789 | Rv3807c | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | 0.645 |
Rv3789 | aftA | Rv3789 | Rv3792 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Arabinofuranosyltransferase AftA; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. Belongs to the glycosyltransf [...] | 0.911 |
Rv3789 | dprE1 | Rv3789 | Rv3790 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...] | 0.965 |
Rv3789 | dprE2 | Rv3789 | Rv3791 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Decaprenylphosphoryl-D-2-keto erythro pentose reductase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probab [...] | 0.966 |
Rv3789 | embA | Rv3789 | Rv3794 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable arabinosyltransferase A; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.882 |
Rv3789 | embB | Rv3789 | Rv3795 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.874 |
Rv3789 | embC | Rv3789 | Rv3793 | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.964 |
Rv3789 | ubiA | Rv3789 | Rv3806c | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | Decaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). The enzyme favors polyprenyl phosphate with 50-60 carbon atoms uses C-75 polyprenyl phosphate less efficiently than C-50 or C-60. Belongs to the UbiA prenyltransferase family. | 0.798 |
Rv3807c | Rv3789 | Rv3807c | Rv3789 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family. | 0.645 |
Rv3807c | aftA | Rv3807c | Rv3792 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | Arabinofuranosyltransferase AftA; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. Belongs to the glycosyltransf [...] | 0.539 |
Rv3807c | dprE1 | Rv3807c | Rv3790 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through [...] | 0.879 |
Rv3807c | dprE2 | Rv3807c | Rv3791 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | Decaprenylphosphoryl-D-2-keto erythro pentose reductase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D- arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probab [...] | 0.800 |
Rv3807c | embA | Rv3807c | Rv3794 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | Probable arabinosyltransferase A; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan. | 0.457 |
Rv3807c | embB | Rv3807c | Rv3795 | Possible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR) (By similarity). | Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family. | 0.568 |