STRINGSTRING
CDX4 CDX4 CHIC1 CHIC1 KDSR KDSR FGF4 FGF4 PRR16 PRR16 CYP26A1 CYP26A1 LMO2 LMO2 TBX6 TBX6 CHST15 CHST15 LCOR LCOR SPATA22 SPATA22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDX4Homeobox protein CHOX-CAD2; Belongs to the Caudal homeobox family. (263 aa)    
Predicted Functional Partners:
CHIC1
Erf4 domain-containing protein.
 
    
 0.717
KDSR
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.647
FGF4
Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity).
    
 
 0.586
PRR16
Proline rich 16.
      
 0.571
CYP26A1
Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]
      
 0.538
LMO2
LIM domain only 2.
      
 0.517
TBX6
T-box-containing protein TBX6L; May be involved in regulating somitogenesis.
   
 
 0.511
CHST15
Carbohydrate sulfotransferase 15.
      
 0.501
LCOR
Ligand dependent nuclear receptor corepressor.
      
 0.481
SPATA22
Spermatogenesis associated 22.
      
 0.467
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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