node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BOC | CDON | ENSGALP00000024403 | ENSGALP00000044568 | BOC cell adhesion associated, oncogene regulated. | Cell adhesion associated, oncogene regulated. | 0.908 |
BOC | GAS1 | ENSGALP00000024403 | ENSGALP00000028297 | BOC cell adhesion associated, oncogene regulated. | Growth arrest specific 1. | 0.984 |
BOC | HHIP | ENSGALP00000024403 | ENSGALP00000050894 | BOC cell adhesion associated, oncogene regulated. | Hedgehog interacting protein. | 0.727 |
BOC | IHH | ENSGALP00000024403 | ENSGALP00000018493 | BOC cell adhesion associated, oncogene regulated. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.978 |
BOC | LRP2 | ENSGALP00000024403 | ENSGALP00000017630 | BOC cell adhesion associated, oncogene regulated. | LDL receptor related protein 2. | 0.900 |
BOC | PTCH1 | ENSGALP00000024403 | ENSGALP00000020572 | BOC cell adhesion associated, oncogene regulated. | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal; Belongs to the patched family. | 0.987 |
BOC | PTCH2 | ENSGALP00000024403 | ENSGALP00000046301 | BOC cell adhesion associated, oncogene regulated. | Patched 2. | 0.958 |
BOC | SHH | ENSGALP00000024403 | ENSGALP00000010292 | BOC cell adhesion associated, oncogene regulated. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.983 |
BOC | SMO | ENSGALP00000024403 | ENSGALP00000048984 | BOC cell adhesion associated, oncogene regulated. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). | 0.679 |
CDON | BOC | ENSGALP00000044568 | ENSGALP00000024403 | Cell adhesion associated, oncogene regulated. | BOC cell adhesion associated, oncogene regulated. | 0.908 |
CDON | GAS1 | ENSGALP00000044568 | ENSGALP00000028297 | Cell adhesion associated, oncogene regulated. | Growth arrest specific 1. | 0.985 |
CDON | HHIP | ENSGALP00000044568 | ENSGALP00000050894 | Cell adhesion associated, oncogene regulated. | Hedgehog interacting protein. | 0.684 |
CDON | IHH | ENSGALP00000044568 | ENSGALP00000018493 | Cell adhesion associated, oncogene regulated. | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. | 0.982 |
CDON | LRP2 | ENSGALP00000044568 | ENSGALP00000017630 | Cell adhesion associated, oncogene regulated. | LDL receptor related protein 2. | 0.926 |
CDON | PTCH1 | ENSGALP00000044568 | ENSGALP00000020572 | Cell adhesion associated, oncogene regulated. | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal; Belongs to the patched family. | 0.990 |
CDON | PTCH2 | ENSGALP00000044568 | ENSGALP00000046301 | Cell adhesion associated, oncogene regulated. | Patched 2. | 0.952 |
CDON | SHH | ENSGALP00000044568 | ENSGALP00000010292 | Cell adhesion associated, oncogene regulated. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.993 |
CDON | SMO | ENSGALP00000044568 | ENSGALP00000048984 | Cell adhesion associated, oncogene regulated. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). | 0.775 |
GAS1 | BOC | ENSGALP00000028297 | ENSGALP00000024403 | Growth arrest specific 1. | BOC cell adhesion associated, oncogene regulated. | 0.984 |
GAS1 | CDON | ENSGALP00000028297 | ENSGALP00000044568 | Growth arrest specific 1. | Cell adhesion associated, oncogene regulated. | 0.985 |